Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson’s Disease
Abstract Parkinson’s Disease (PD) is currently the most rapid growing neurodegenerative disease and over the past generation, its global burden…
Phytocannabinoids
From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
Abstract Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that…
Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
Abstract Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is…
Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects
Abstract Cannabidiol (CBD) is one of the prominent phytocannabinoids found in Cannabis sativa, differentiating from Δ9-tetrahydrocannabinol (THC) for its non-intoxicating…
Absence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors
Abstract Introduction: Compounds present in Cannabis sativa such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects.…
The dimerization of Δ9-tetrahydrocannabinolic acid A (THCA-A)
Abstract The renewed interest in dimeric salicylates as broad-spectrum anti-inflammatory and anti-diabetic agents provided a rationale to investigate the dimerization…
Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation
Abstract Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research…
New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders
Abstract Following the discovery of the endocannabinoid system and its potential as a therapeutic target for various pathological conditions, growing…
Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
Abstract Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current…
Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases
Abstract Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the well-known psychotropic activity. C. Sativa is…