Multi-dimensional analysis reveals the potential of PDK4 as a tumor biomarker and target for immunotherapy
Abstract Purpose: To explore the clinical significance of pyruvate dehydrogenase kinase 4 (PDK4) in pan-cancer and its potential as a…
(phospho)lipid metabolism
The Role of NSUN Family Genes in m5C Methylation and Diseases
Abstract 5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification…
The role of natural compounds in modulation of small extracellular vesicle biogenesis and lipid metabolism in cancer
Abstract Small extracellular vesicles (sEVs) are vesicles of 15–150 nm in diameter secreted by cells and contain biological compounds that…
Metabolism, pharmacokinetics, and bioavailability of cannabigerol in horses following intravenous and oral administration with micellar and oil formulations
Abstract Introduction: Cannabigerol (CBG) is a non-psychoactive cannabinoid with growing interest in veterinary medicine; however, its pharmacokinetic profile in horses…
Molecular pathogenesis of Alzheimer’s disease onset in a mouse model: effects of cannabidiol treatment
Abstract Introduction: Alzheimer’s disease (AD) is a common neurodegenerative condition involving a complex blend of disturbances in synaptic development and…
Metabolism of Cannabidiol in Respiratory-Associated Cells and HepG2-Derived Cells and Molecular Docking of Cannabidiol and Its Metabolites with CYP Enzymes and Cannabinoid Receptors
Abstract Cannabidiol (CBD) has been reported in medical applications for various indications. The enzymatic metabolism of CBD is not fully…
Unraveling the Complexity of Plant Trichomes: Models, Mechanisms, and Bioengineering Strategies
Abstract Trichomes—microscopic appendages on the plant epidermis—play vital roles as both protective barriers and specialized biosynthetic factories. Acting as the…
ITGA3–MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways
Abstract Background: Studies have examined the role of integrin α3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional and…
In vitro metabolism of Benzyl-4CN-BUTINACA and MDMB-4CN-BUTINACA using human hepatocytes and LC-QToF-MS analysis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00204-025-04018-y. Article type: Research Article Keywords: New psychoactive substances,…
An In Vitro Phytohormone Survey Reveals Concerted Regulation of the Cannabis Glandular Trichome Disc Cell Proteome
Abstract Cannabis (Cannabis sativa L.) flower glandular trichomes (GTs) are the main site of cannabinoid synthesis. Phytohormones, such as jasmonic…