Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse
Abstract Introduction: Cannabis holds therapeutic potential; however, activation of the type 1 cannabinoid receptor (CB1R) via Δ9-tetrahydrocannabinol (THC) is also…
pharmacodynamics
Predicting Δ‑9-Tetrahydrocannabinol-Induced Psychoactive and Cognitive Effects: A PBPK–PD Approach to Quantifying Feeling High and Reduced Alertness
Abstract The increasing use of cannabis for medicinal and recreational purposes highlights the need to understand its psychoactive effects. Δ-9-tetrahydrocannabinol…
Differential effects of S-allyl cysteine and cannabidiol on enterocytic and plasma amyloid-β in db/db diabetic mice
Abstract Peripheral amyloid-beta (Aβ), including those in bloodstream and intestine, is implicated in the pathogenesis of Alzheimer’s disease (AD). Additionally,…
Cannabidiol as an immune modulator: A comprehensive review
Abstract Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has emerged as a promising therapeutic agent due to its…
Preliminary pharmacokinetic and psychophysical investigations after controlled oral and inhalative consumption of hexahydrocannabinol (HHC)
Abstract The semi-synthetic cannabinoid hexahydrocannabinol (HHC) has become a highly discussed topic in forensic toxicology since 2022 due to its…
Quantifying Heart Rate Changes After Delta-9-Tetrahydrocannabinol Administration Using a PBPK-PD Model in Healthy Adults
Abstract Background: As cannabis becomes legal in several U.S. states, the risk of THC-induced tachycardia increases. This study aimed to…
Utilization of Cannabidiol in Post-Organ-Transplant Care
Abstract Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis sativa, widely recognized for its therapeutic potential.…
GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice
Abstract G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about…
Strategies to Improve Cannabidiol Bioavailability and Drug Delivery
Abstract The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development. The aim of this review was to examine…
Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database
Abstract Cancer patients could combine herbal treatments with their chemotherapy. We consulted VigiBase, a WHO database of individual case safety…