Structural basis of THC analog activity at the Cannabinoid 1 receptor
Abstract Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions,…
Permeation and transport
Cannabidiol inhibits Nav channels through two distinct binding sites
Abstract Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective treatment for some forms of epilepsy and pain.…
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Abstract TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with…
Structural basis of sodium-dependent bile salt uptake into the liver
Abstract The liver takes up bile salts from blood to generate bile, enabling absorption of lipophilic nutrients and excretion of…