The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy
Abstract Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in…
PDE4 inhibitors
Ibudilast for alcohol use disorder: study protocol for a phase II randomized clinical trial
Abstract Background: Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly…