Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy; it is the most common acute leukemia in adults. AML…
oxidative phosphorylation
Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12974-024-03204-6. Article type: Research Article Keywords: Alzheimer’s disease, Transient…
Tau protein profiling in tauopathies: a human brain study
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s13024-024-00741-9. Article type: Research Article Keywords: Tau, Tauopathies, Mass…
Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites
Abstract Tau proteins within the adult central nervous system (CNS) are found to be abnormally aggregated into heterogeneous filaments in…
Unique Metabolic Contexts Sensitize Cancer Cells and Discriminate between Glycolytic Tumor Types
Abstract Simple Summary: We sought to assess cancer cell viability in the context of glycolytic versus oxidative phosphorylation carbon source…
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-022-01436-2. Article type: Research Article Keywords: Down syndrome, Tau,…
Purification and Biochemical Characterization of Sucrose synthase from the Stem of Nettle (Urtica dioica L.)
Abstract Sucrose synthase is a key enzyme in sucrose metabolism as it saves an important part of sucrose energy in…