An improved epigenetic counter to track mitotic age in normal and precancerous tissues
Abstract The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a…
ovarian cancer stem cells
Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
Abstract Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that…
A Pan-Cancer Landscape of ABCG2 across Human Cancers: Friend or Foe?
Abstract Emerging evidence from research or clinical studies reported that ABCG2 (ATP-binding cassette sub-family G member 2) interrelates with multidrug…
Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells
Abstract Transcription replication collisions (TRCs) constitute a major intrinsic source of genome instability but conclusive evidence for a causal role…
Disulfiram/Copper Suppresses Cancer Stem Cell Activity in Differentiated Thyroid Cancer Cells by Inhibiting BMI1 Expression
Abstract Differentiated thyroid carcinomas (DTCs), which have papillary and follicular types, are common endocrine malignancies worldwide. Cancer stem cells (CSCs)…
Anti-Cancer Activity of Cannabis sativa Phytocannabinoids: Molecular Mechanisms and Potential in the Fight against Ovarian Cancer and Stem Cells †
Abstract Simple Summary: Ovarian cancer is the most lethal gynecological malignancy. Cancer stem cells have been implicated in tumor initiation,…
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities
Abstract Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account…
Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
Abstract Currently, there is no effective therapy against lung cancer due to the development of resistance. Resistance contributes to disease…
Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells
Abstract Immune checkpoint blockade (ICB) has become one of the most promising approaches to activating antitumor immunity. However, only a…
Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells
Abstract The ‘cancer cell fusion’ theory is controversial due to the lack of methods available to identify hybrid cells and…