Abstract Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial “hedonic hotspot” in nucleus accumbens (NAc) shell enhances…
Abstract Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ9-THC) exposure, however, the molecular underpinnings of this…
Abstract Introduction: Repeated administration of abused drugs, including Δ9-tetrahydrocannabinol (THC), induces the stable transcription factor ΔFosB in dopaminergic terminal field…
Abstract Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects…
Abstract Introduction: Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but…
Abstract Since the identification and cloning of the major cannabinoid receptor expressed in the brain almost 25 years ago research…
Abstract Motherhood involves a switch in natural rewards, whereby offspring become highly rewarding. Nucleus accumbens (NAC) is a key CNS…
Abstract 2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from…
Abstract Recent evidence has implicated the endocannabinoid (eCB) system in nicotine addiction. The eCB system also has an important role…
Abstract To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology…