“Invisible” pancreatic masses identified by EUS by the “ductal cutoff sign”
Abstract Making a tissue diagnosis of pancreatic adenocarcinoma is best accomplished by EUS and fine-needle aspiration (FNA) of the lesion.…
nucleus accumbens
The neuropsychopharmacology of cannabis: A review of human imaging studies
Abstract The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in…
Endocannabinoid-Enhanced “Liking” in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals
Abstract Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial “hedonic hotspot” in nucleus accumbens (NAc) shell enhances…
Chronic Δ9-THC Exposure Differently Affects Histone Modifications in the Adolescent and Adult Rat Brain
Abstract Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ9-THC) exposure, however, the molecular underpinnings of this…
Δ9-Tetrahydrocannabinol Experience Influences ΔFosB and Downstream Gene Expression in Prefrontal Cortex
Abstract Introduction: Repeated administration of abused drugs, including Δ9-tetrahydrocannabinol (THC), induces the stable transcription factor ΔFosB in dopaminergic terminal field…
Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature
Abstract Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects…
Variable activation in striatal subregions across components of a social influence task in young adult cannabis users
Abstract Introduction: Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but…
Endocannabinoids and striatal function: implications for addiction-related behaviours
Abstract Since the identification and cloning of the major cannabinoid receptor expressed in the brain almost 25 years ago research…
Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens
Abstract Motherhood involves a switch in natural rewards, whereby offspring become highly rewarding. Nucleus accumbens (NAC) is a key CNS…
Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell
Abstract 2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from…