nucleosome

July 30, 2024

Autoregulatory mechanism of enzyme activity by the nuclear localization signal of lysine-specific demethylase 1

Abstract The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted structural elements, contains a nuclear localization…

December 7, 2022

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations

Abstract The H3K4me3 chromatin modification, a hallmark of promoters of actively transcribed genes, is dynamically removed by the KDM5 family…