Understanding the Mechanisms of Action and Effects of Drugs of Abuse
Abstract Aim. Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the negative…
non-opioids
Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region
Abstract The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and…
The endocannabinoid system and breathing
Abstract Recent changes in cannabis accessibility have provided adjunct therapies for patients across numerous disease states and highlights the urgency…
An fMRI analysis of verbal and non-verbal working memory in people with a past history of opioid dependence
Abstract Introduction: Working memory describes the ability to maintain and manipulate information held in mind, and it is a fundamental…
Cannabis Use and Its Association With Thirty- and Ninety-Day Hospital Readmissions for Patients Admitted for an Inflammatory Bowel Disease Exacerbation
Abstract Background: Though viewed as a potentially safer palliative alternative to opioids, studies of cannabis use for inflammatory bowel disease…
Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination—the SPIRAL study
Abstract Background: Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time…
Specific polysubstance use patterns predict relapse among patients entering opioid use disorder treatment
Abstract Polysubstance use patterns over the 28-days pre OUD treatment were identified. Polysubstance use patterns were differentially related to relapse…
Perceived Efficacy, Reduced Prescription Drug Use, and Minimal Side Effects of Cannabis in Patients with Chronic Orthopedic Pain
Abstract Introduction: Although cannabis is widely used for the treatment of chronic pain, most research relies on patient self-report and…
High-CBD Cannabis Vapor Attenuates Opioid Reward and Partially Modulates Nociception in Female Rats
Abstract Chronic pain patients report analgesic effects when using cannabidiol (CBD), a phytocannabinoid found in whole-plant cannabis extract (WPE). Several…
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling
Abstract Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most…