Unregulated Substance Abuse and Systemic Inflammation Markers: A Review
Abstract Aim: There is an urgent need for systematic and well-designed studies to clarify the role of systemic inflammatory parameters,…
NLRP3 inflammasome
Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV
Abstract Introduction: Human immunodeficiency virus (HIV) infection is often associated with chronic inflammation and cognitive dysfunction in people living with…
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature
Abstract Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and…
The association between hematological markers of inflammation and chronic cannabis use: a systematic review and meta-analysis of observational studies
Abstract Introduction: Cannabinoids, both natural and synthetic, are a subject of scientific interest. Cannabis is widely used, and its impact…
P2X7 receptors from the perspective of NLRP3 inflammasome pathway in depression: Potential role of cannabidiol
Abstract Many patients with depressive disorder do not respond to conventional antidepressant treatment. There is an ongoing interest in investigating…
Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
Abstract Background: In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations in…
Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
Abstract During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of…
The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol
Abstract Many psychiatric patients do not respond to conventional therapy. There is a vast effort to investigate possible mechanisms involved…
Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro
Abstract Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most studied group of compounds obtained from Cannabis sativa because…
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome–Pyroptosis Pathway
Abstract Alcohol abuse and high-fat diet–induced liver diseases have been the most prevalent chronic liver diseases and the leading reasons…