NF-κB

September 29, 2022

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

Abstract Cannabidiol (CBD), the major non-psychoactive phytocannabinoid of Cannabis sativa L., is one of the most studied compounds in pharmacotherapeutic…

June 9, 2022

Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells

Abstract The objective of our present work was to explore the possible enhanced anti-neuroinflammatory ability of Aspergillus oryzae fermented hemp…

January 10, 2022

Hempseed (Cannabis sativa) Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line

Abstract WVSPLAGRT (H2) and IGFLIIWV (H3) are two transepithelial transported intestinal peptides obtained from the hydrolysis of hempseed protein with…

September 22, 2021

CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome–Pyroptosis Pathway

Abstract Alcohol abuse and high-fat diet–induced liver diseases have been the most prevalent chronic liver diseases and the leading reasons…

December 13, 2016

Targeting calcium signaling in cancer therapy

Abstract The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating…

November 1, 2014

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Keywords: PPAR gamma, Nuclear receptor, Natural product, Nutrition, Diabetes, 9-(, AF-2, activation function-2, CAP, c-Cbl-associated protein, Cdk5, cyclin-dependent kinase 5,…

April 24, 2012

3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells

Abstract Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as…