Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance
Abstract Simple Summary: A few types of cancers are currently as challenging and difficult to defeat as pancreatic ductal adenocarcinoma.…
neuropathic pain
Comparison of the Effectiveness and Tolerability of Nabiximols (THC:CBD) Oromucosal Spray versus Oral Dronabinol (THC) as Add-on Treatment for Severe Neuropathic Pain in Real-World Clinical Practice: Retrospective Analysis of the German Pain e-Registry
Abstract Purpose: To compare the effectiveness and tolerability of add-on treatment with nabiximols (NBX: delta-9-tetrahydrocannabinol: cannabidiol) oromucosal spray or oral…
Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
Abstract Despite the importance of pain as a warning physiological system, chronic neuropathic pain is frequently caused by damage in…
The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial
Abstract Disease or acquired damage to the central nervous system frequently causes disabling spasticity and central neuropathic pain (NP), both…
Combination Therapy for Neuropathic Pain: A Review of Recent Evidence
Abstract Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive decrease in the estimated effect of NP…
A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment
Abstract Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease.…
Pain in NMOSD and MOGAD: A Systematic Literature Review of Pathophysiology, Symptoms, and Current Treatment Strategies
Abstract Neuromyelitis optica spectrum disorders (NMOSDs) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are autoimmune inflammatory disorders of the central nervous…
A Review of Scientific Evidence for THC:CBD Oromucosal Spray (Nabiximols) in the Management of Chronic Pain
Abstract The 20% prevalence of chronic pain in the general population is a major health concern given the often profound…
Effectiveness and tolerability of THC:CBD oromucosal spray as add-on measure in patients with severe chronic pain: analysis of 12-week open-label real-world data provided by the German Pain e-Registry
Abstract Objective: To evaluate effectiveness, tolerability and safety of an oromucosal spray containing Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as add-on…
Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
Abstract Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current…