Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease
Abstract Glia form a central component of the nervous system whose varied activities sustain an environment that is optimised for…
neurodegeneration
Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration
Abstract Background: The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and…
Dural lymphatics regulate clearance of extracellular tau from the CNS
Abstract Background: Alzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates…
Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their…
Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch
Abstract Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 chaperone family that localizes to neuronal synaptic vesicles. Impaired…
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
Abstract Background: Alzheimer’s disease is associated with amyloid-beta (Aβ)-induced microglia activation. This pro-inflammatory response promotes neuronal damage, and therapies are…
Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups
Abstract Background: In theory, cerebral biopsies could provide the diagnosis in a significant proportion of patients with neurodegenerative diseases, however,…