Cannabinoids in the Modulation of Oxidative Signaling
Abstract Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), and components of the endocannabinoids system, such as N-arachidonoylethanolamide…
neurodegeneration
Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases?
Abstract This work is a literature review, presenting the current state of the use of cannabinoids on neurodegenerative diseases. The…
Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments
Abstract Alzheimer’s disease (AD) is a frequent and disabling neurodegenerative disorder, in which astrocytes participate in several pathophysiological processes including…
Drug reprofiling history and potential therapies against Parkinson’s disease
Abstract Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old”…
Peroral Exposure to Cannabis Sativa Ethanol Extract Caused Neuronal Degeneration and Astrogliosis in Wistar Rats’ Prefrontal Cortex
Abstract Background: Despite widespread concerns about its possible side effects, notably on the prefrontal cortex (PFC), which mediates cognitive processes,…
Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase
Abstract Simple Summary: Kynurenine-3-monooxygenase (KMO) is an enzyme in the neurotoxic branch of the kynurenine pathway (KP) and is a…
Molecular Imaging in Parkinsonian Disorders—What’s New and Hot?
Abstract Highlights: Abstract: Neurodegenerative parkinsonian disorders are characterized by a great diversity of clinical symptoms and underlying neuropathology, yet differential…
Medicinal Cannabis and Central Nervous System Disorders
Abstract Cannabinoids, including those found in cannabis, have shown promise as potential therapeutics for numerous health issues, including pathological pain…
Advances in clinical basic research: Performance, treatments, and mechanisms of Parkinson disease
Abstract The loss of neuronal in the substantia nigra of the elderly contributes to striatal damage and plays a critical…
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-021-01196-5. Article type: Research Article Keywords: TAU, Cannabinoid receptor,…