Mechanistic origin of partial agonism of tetrahydrocannabinol for cannabinoid receptors
Abstract Cannabinoid receptor 1 (CB1) is a therapeutically relevant drug target for controlling pain, obesity, and other central nervous system…
negative allosteric modulators
In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators
Abstract Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal…
Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer’s disease?
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the 50 million worldwide cases of dementia…