myotonia

February 16, 2023

Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism

Abstract Background: Severe muscle stiffness (SMS) in dogs with hypercortisolism (HC) is uncommon. Objectives: To evaluate signalment, presentation, treatments, and…

September 2, 2021

Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Nav1.4 in Its Slow-Inactivated State and Inhibits Sodium Current

Abstract Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the myotonia resulting from sodium channelopathy, which…

May 24, 2021

Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications

Abstract Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels’ function can lead to many pathophysiological…