The role of distinct APOBEC/ADAR mRNA levels in mutational signatures linked to aging and ultraviolet radiation
Abstract The APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs.…
Mutational signatures
A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs
Abstract Background: We previously reported a familial thyroid follicular cell carcinoma (FCC) in a large number of Dutch German longhaired…
Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma
Abstract Background: Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients’ clinical outcome.…
Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes
Abstract Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have…