PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation
Abstract Background: Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great…
molecular target
Research progress in the management of vascular disease with cannabidiol: a review
Abstract The morbidity and mortality rates associated with vascular disease (VD) have been gradually increasing. Currently, the most common treatment…
Molecular and Cellular Mechanisms of Action of Cannabidiol
Abstract Cannabidiol (CBD) is the primary non-psychoactive chemical from Cannabis Sativa, a plant used for centuries for both recreational and…
Therapeutic potential of TRPM8 channels in cancer treatment
Abstract Cancer is a multifactorial process associated with changes in signaling pathways leading to cell cycle variations and gene expression.…
Cannabidiol Signaling in the Eye and Its Potential as an Ocular Therapeutic Agent
Abstract Cannabidiol (CBD), the major non-intoxicating constituent of Cannabis sativa, has gained recent attention due to its putative therapeutic uses…
Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?
Abstract In late December 2019, a novel coronavirus (SARS-CoV-2 or CoV-19) appeared in Wuhan, China, causing a global pandemic. SARS-CoV-2…
A Guide to Targeting the Endocannabinoid System in Drug Design
Abstract The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character.…
Signaling Complexity Measured by Shannon Entropy and Its Application in Personalized Medicine
Abstract Traditional approaches to cancer therapy seek common molecular targets in tumors from different patients. However, molecular profiles differ between…
An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a…