Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus
Abstract Hippocampal ripples project reactivated memories to many brain areas, and recently it has been proposed that different types of…
Molecular neuroscience
Impact of cannabinoids on synapse markers in an SH-SY5Y cell culture model
Abstract Patients suffering from schizophrenic psychosis show reduced synaptic connectivity compared to healthy individuals, and often, the use of cannabis…
Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay
Abstract The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived,…
Design of amyloidogenic peptide traps
Abstract Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many diseases. We describe…
GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice
Abstract G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about…
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density
Abstract Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially…
Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region
Abstract The non-euphorigenic phytocannabinoid cannabidiol (CBD) has been used successfully to treat childhood-onset epilepsies. These conditions are associated with developmental…
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release,…
Investigating TSPO levels in occupation-related posttraumatic stress disorder
Abstract Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the…
Targeted metabolomics reveals aberrant profiles of serum bile acids in patients with schizophrenia
Abstract Emerging evidence indicates that bile acids (BAs), which are signaling molecules that regulate metabolism and inflammation, appear to be…