The close interaction between hypoxia-related proteins and metastasis in pancarcinomas
Abstract Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access to nutrients due to poor vascularization in…
Molecular medicine
Patient-level proteomic network prediction by explainable artificial intelligence
Abstract Understanding the pathological properties of dysregulated protein networks in individual patients’ tumors is the basis for precision therapy. Functional…
UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol
Abstract UV radiation is known to induce a multiple changes in the metabolism of skin-building cells, what can affect the…
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
Abstract Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight…
Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling
Abstract While classical cannabinoid receptors are known to crucially impact on myocardial infarction (MI) repair, a function of the cannabinoid-sensitive…
Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans
Abstract Delta-9-tetrahydrocannabinol (THC) is known to modulate immune response in peripheral blood cells. The mechanisms of THC’s effects on gene…
A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
Abstract Salicylic acid (SA) is the major metabolite and active ingredient of aspirin; both compounds reduce pain, fever, and inflammation.…