Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Abstract MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological…
molecular mechanisms
Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers
Abstract Cancer is one of the primary causes of human mortality and a significant barrier to increasing human life expectancy.…
Cuproptosis: a promising new target for breast cancer therapy
Abstract Breast cancer (BC) is the leading cause of cancer-related mortality among women globally, affecting approximately one-quarter of all female…
Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review
Abstract Background: Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder…
Palmitoylethanolamide: A Natural Compound for Health Management
Abstract All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases,…
Expression level of long non-coding RNA colon adenocarcinoma hypermethylated serves as a novel prognostic biomarker in patients with thyroid carcinoma
Abstract The present study attempts to identify the prognostic value and potential mechanism of action of colorectal adenocarcinoma hypermethylated (CAHM)…
Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors
Abstract Endocannabinoid system (ECS) has been identified ever since cannabinoid, an active substance of Cannabis, was known to interact with…
Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
Abstract Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is…
The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies
Abstract Neurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that…
Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs
Abstract Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. Despite…