Abstract Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by…
Abstract Encapsulated cell-based therapies for solid tumors have shown promising results in pre-clinical settings. However, the inability to culture encapsulated…
Abstract A general method to generate biosensors for user-defined molecules could provide detection tools for a wide range of biological…
Abstract The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite…