Abstract To elucidate the immunological mechanisms underlying T cell exhaustion in papillary thyroid carcinoma (PTC) by integrating bulk and single-cell…
Abstract Papillary thyroid cancer (PTC) is an ever-increasing cancer type worldwide, and greatly decreases the life quality and affects survival…
Abstract Background: Colorectal cancer (CRC) is a complex, heterogeneous disease characterized by frequent relapses and metastasis. Previous studies have reported…
Abstract Background: The human FOXM1 transcription factor controls cell cycle progression and genome stability, and it has been correlated to…
Abstract Background: DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear.…
Abstract Background: RNA sequencing combined with machine learning techniques has provided a modern approach to the molecular classification of cancer.…
Abstract Background: Prediction of patient survival from tumor molecular ‘-omics’ data is a key step toward personalized medicine. Cox models…
Abstract Simple Summary: Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer. In recent years, broad application of NGS…
Abstract Simple Summary: Traditionally, chemotherapy has been approached through one-size-fits-all strategies. However, personalized oncology would allow a rational approach to…
Abstract Simple Summary: RAS mutations have been reported in a wide range of thyroid cancer histological types, from benign to…