Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
Abstract Microbial production of cannabinoids promises to provide a consistent, cheaper, and more sustainable supply of these important therapeutic molecules.…
metabolic engineering
In planta Female Flower Agroinfiltration Alters the Cannabinoid Composition in Industrial Hemp (Cannabis sativa L.)
Abstract Industrial hemp is a diploid (2n = 20), dioecious plant, and an essential source of various phytochemical productions. More…
Biosynthesis of Nature-Inspired Unnatural Cannabinoids
Abstract Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one…
The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems
Abstract The medicinal properties of cannabis and the its legal status in several countries and jurisdictions has spurred the massive…
Metabolic Engineering Strategies of Industrial Hemp (Cannabis sativa L.): A Brief Review of the Advances and Challenges
Abstract Industrial hemp (Cannabis sativa L.) is a diploid (2n = 20), dioecious plant that is grown for fiber, seed,…
Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system
Abstract Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut.…
A cell-free platform for the prenylation of natural products and application to cannabinoid production
Abstract Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have…