Metabolic Engineering of Nicotiana benthamiana to Produce Cannabinoid Precursors and Their Analogues
Abstract In recent years, the perspective towards the use of cannabis has slowly shifted from being an illicit drug to…
metabolic engineering
Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica
Abstract Engineering microbes to produce plant-derived natural products provides an alternate solution to obtain bioactive products. Here we report a…
Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
Abstract Microbial production of cannabinoids promises to provide a consistent, cheaper, and more sustainable supply of these important therapeutic molecules.…
In planta Female Flower Agroinfiltration Alters the Cannabinoid Composition in Industrial Hemp (Cannabis sativa L.)
Abstract Industrial hemp is a diploid (2n = 20), dioecious plant, and an essential source of various phytochemical productions. More…
Biosynthesis of Nature-Inspired Unnatural Cannabinoids
Abstract Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one…
The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems
Abstract The medicinal properties of cannabis and the its legal status in several countries and jurisdictions has spurred the massive…
Metabolic Engineering Strategies of Industrial Hemp (Cannabis sativa L.): A Brief Review of the Advances and Challenges
Abstract Industrial hemp (Cannabis sativa L.) is a diploid (2n = 20), dioecious plant that is grown for fiber, seed,…
A cell-free platform for the prenylation of natural products and application to cannabinoid production
Abstract Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have…