Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil
Abstract In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and…
Mechanism of Action
Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R
Abstract G protein-coupled receptors (GPCRs) are important therapeutic drug targets for a wide range of diseases. Upon activation, GPCRs can…
Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action
Abstract Background: Cannabidiol (CBD) is the primary non-psychoactive component of cannabis. Consumption of CBD is increasing rapidly as it is…
Pharmacodynamic rationale for the choice of antiseizure medications in the paediatric population
Abstract In the landscape of paediatric epilepsy treatment, over 20 anti-seizure medications (ASMs) have gained approval from Drug Regulatory Agencies,…
Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
Abstract The development of new antibiotics is urgently needed to combat the threat of bacterial resistance. New classes of compounds…
Emerging Antifungal Targets and Strategies
Abstract Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is…
Defining molecular glues with a dual-nanobody cannabidiol sensor
Abstract “Molecular glue” (MG) is a term coined to describe the mechanism of action of the plant hormone auxin and…
Cannabidiol Signaling in the Eye and Its Potential as an Ocular Therapeutic Agent
Abstract Cannabidiol (CBD), the major non-intoxicating constituent of Cannabis sativa, has gained recent attention due to its putative therapeutic uses…
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
Abstract As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic…
Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent
Abstract Introduction: Highly purified cannabidiol (CBD) (approved as Epidiolex® in the United States) has demonstrated efficacy with an acceptable safety…