Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Abstract Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It…
major depressive disorder
Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models
Abstract Patients with a serious mental illness often use cannabis at higher rates than the general population and are also…
Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review
Abstract Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several…
Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
Abstract Cannabis and analogs of Δ9-tetrahydrocannabinol have been used for therapeutic purposes, but their therapeutic use remains limited because of…
A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness
Abstract Background: Severe mental illness (SMI), including schizophrenia, bipolar disorder and severe depression, is responsible for a substantial proportion of…
Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases
Abstract Psychiatric disorders such as schizophrenia and major depressive disorder were thought to be caused by neurotransmitter abnormalities. Patients with…