FHL2 facilitates LUSC growth and therapy resistance through PI3K/AKT/mTOR activation
Abstract Four and a half LIM domain protein 2 (FHL2) plays a key role in tumorigenesis and progression. This study…
LUSC
SEPT9: From pan-cancer to lung squamous cell carcinoma
Abstract Background: SEPT9 is a pivotal cytoskeletal GTPase that regulates diverse biological processes encompassing mitosis and cytokinesis. While previous studies…
Pan-Cancer Analysis Reveals Long Non-coding RNA (lncRNA) Embryonic Stem Cell-Related Gene (ESRG) as a Promising Diagnostic and Prognostic Biomarker
Abstract Background: Embryonic stem cell-related gene (ESRG; also known as HESRG) is a long non-coding RNA (lncRNA). It is involved…
FAM20A: a potential diagnostic biomarker for lung squamous cell carcinoma
Abstract Background: Lung squamous cell carcinoma (LUSC) ranks among the carcinomas with the highest incidence and dismal survival rates, suffering…
Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues
Abstract Endothelial cells (ECs) play an important role in tumor progression. Currently, the main target of anti-angiogenic therapy is the…
Integrative analysis deciphers the heterogeneity of cancer-associated fibroblast and implications on clinical outcomes in ovarian cancers
Keywords: scRNA-seq, Single-cell RNA-sequencing, CAFs, Cancer-associated fibroblasts, HGSOC, High-grade serous ovarian carcinoma, TCGA, The Cancer Genomics Atlas, LUAD, Lung adenocarcinoma,…
Comprehensive analysis of tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2): A potential novel pan-cancer immune checkpoint
Keywords: LAML, Acute Myeloid Leukemia, BLCA, Bladder Urothelial Carcinoma, BRCA, Breast invasive carcinoma, CESC, Cervical squamous cell carcinoma and endocervical…
Comprehensive analysis of the novel omicron receptor AXL in cancers
Keywords: COVID-19, coronavirus disease 2019, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, ACE2, angiotensin-converting enzyme 2, AXL, anexelekto, UMAP, uniform…
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers
Keywords: AUC, area under the curve, CCLE, cancer cell line encyclopedia, HR, hazard ratio, ROC, receiver operating characteristic, SHCBP1, Shc…