EZH2 as a prognostic-related biomarker in lung adenocarcinoma correlating with cell cycle and immune infiltrates
Abstract Backgrounds: It has been observed that high levels of enhancer of zeste homolog 2 (EZH2) expression are associated with…
LUAD
Pan-cancer landscape of CENPO and its underlying mechanism in LUAD
Abstract Background: Centromere protein O (CENPO) is a newly discovered constitutive centromeric protein, associated with cell death. However, little is…
NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma
Abstract Recent discoveries have suggested that the F-actin capping protein α1 subunit (CAPZA1) in various human tumors could play a…
Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues
Abstract Endothelial cells (ECs) play an important role in tumor progression. Currently, the main target of anti-angiogenic therapy is the…
Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations
Abstract The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions…
Integrative analysis deciphers the heterogeneity of cancer-associated fibroblast and implications on clinical outcomes in ovarian cancers
Keywords: scRNA-seq, Single-cell RNA-sequencing, CAFs, Cancer-associated fibroblasts, HGSOC, High-grade serous ovarian carcinoma, TCGA, The Cancer Genomics Atlas, LUAD, Lung adenocarcinoma,…
Pan-cancer analysis of UBE2T with a focus on prognostic and immunological roles in lung adenocarcinoma
Abstract Background: Ubiquitin-conjugating enzyme E2 T (UBE2T) is a potential oncogene. However, Pan-cancer analyses of the functional, prognostic and predictive…
Pan-Cancer Analysis and Experimental Validation Identify ACOT7 as a Novel Oncogene and Potential Therapeutic Target in Lung Adenocarcinoma
Abstract Simple Summary: Acyl-CoA thioesterase 7 (ACOT7) is important in regulating cell cycle, cell proliferation, and glucose metabolism. Research on…
Comprehensive analysis of tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2): A potential novel pan-cancer immune checkpoint
Keywords: LAML, Acute Myeloid Leukemia, BLCA, Bladder Urothelial Carcinoma, BRCA, Breast invasive carcinoma, CESC, Cervical squamous cell carcinoma and endocervical…
Comprehensive analysis of the novel omicron receptor AXL in cancers
Keywords: COVID-19, coronavirus disease 2019, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, ACE2, angiotensin-converting enzyme 2, AXL, anexelekto, UMAP, uniform…