Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma
Abstract Background: Autophagy, a vital cellular process, plays a significant role in the development of a spectrum of diseases, notably…
LUAD
Expression of PSMD14 in lung adenocarcinoma and its impact on immune cell infiltration and prognosis: a comprehensive analysis based on RNA and single-cell RNA sequencing
Abstract Background: Lung adenocarcinoma (LUAD) is distinguished by intricate relationships between tumor advancement and the immune microenvironment. The function of…
Pan-cancer analysis identifies CLEC12A as a potential biomarker and therapeutic target for lung adenocarcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12935-025-03755-5. Article type: Research Article Keywords: CLEC12A, Pan-cancer, Biomarker,…
Multi-omics pan-cancer analysis reveals the diagnostic and prognostic value of C8orf76, with experimental validation of its impact on lung adenocarcinoma cell proliferation
Abstract Background: Chromosome 8 open reading frame 76 (C8orf76) is a nuclear protein-encoding gene, has received limited attention in current…
Comprehensive pan-cancer analysis and experiments revealed R3HDM1 as a novel predictive biomarker for prognosis and immune therapy response
Abstract Background: R3HDM1, an RNA binding protein with one R3H domain, remains uncharacterized in terms of its association with tumor…
A comprehensive prognostic and immunological implications of PFKP in pan-cancer
Abstract Background: Phosphofructokinase P (PFKP) is a key rate-limiting enzyme in glycolysis, playing a crucial role in various pathophysiological processes.…
GJB3: a comprehensive biomarker in pan-cancer prognosis and immunotherapy prediction
Abstract Background: A wide range of connexins are situated between normal-normal cells, cancer-cancer cells, and cancer-normal cells. Abnormalities in connexin…
GLIPR2: a potential biomarker and therapeutic target unveiled – Insights from extensive pan-cancer analyses, with a spotlight on lung adenocarcinoma
Abstract Background: Glioma pathogenesis related-2 (GLIPR2), an emerging Golgi membrane protein implicated in autophagy, has received limited attention in current…
Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma
Abstract We found elevated homeodomain-containing gene C10 (HOXC10) showed dual roles in cancers’ prognosis. Some signal pathways associated with tumor…
Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma
Abstract Background: As a member of the mitochondrial ribosomal protein family, mitochondrial ribosomal protein L13 (MRPL13) is responsible for synthesizing…