Lipidome Complexity in Physiological and Pathological Skin Pigmentation
Abstract Skin pigmentation results from complex cellular interactions and is influenced by genetic, environmental, and metabolic factors. Emerging evidence highlights…
Lipidomics
Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
Abstract The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute…
Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury
Abstract E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use.…
Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics
Abstract Cannabis use disorder affects up to 42% of individuals with schizophrenia, correlating with earlier onset, increased positive symptoms, and…
Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidome
Abstract The present studies were undertaken to understand the effects of the commonly used nutraceutical PEA on brain function and…
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids
Abstract Oxysterols and bile acids are interconnected bioactive lipids playing pivotal roles in diverse physiological and pathological processes. For this…
Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol
Abstract UV radiation inducing mutations in melanocytes might cause melanoma. As changes in lipid composition and metabolism are associated with…
Endocannabinoid basis of personality—Insights from animal model of social behavior
Abstract Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns.…
Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping
Abstract The current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances…
Pan-Cancer analysis shows that ACO2 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including hepatocellular carcinoma
Abstract Background: Recent evidence increasingly suggests key roles for the tricarboxylic acid cycle and fatty acid metabolism in tumor progression…