Ligand activation mechanisms of human KCNQ2 channel
Abstract The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can…
Ion transport
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Abstract Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights…
Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B
Abstract Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble metallochaperones…
Effects of Hemp seed soft capsule on colonic ion transport in rats
Abstract AIM: To investigate the effect of Hemp seed soft capsule (HSCC) on colonic ion transport and its related mechanisms…