The critical role of ion channels in kidney disease: perspective from AKI and CKD
Abstract Ion channels, particularly those in the transient receptor potential (TRP) family, play key roles in cellular stress responses like…
ion channels
Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson’s disease
Abstract Pain is a complex phenomenon, and basal ganglia circuitry integrates many aspects of pain including motor, emotional, autonomic, and…
Inflammation—the role of TRPA1 channel
Abstract Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a…
Ion Channels in Gliomas—From Molecular Basis to Treatment
Abstract Ion channels provide the basis for the nervous system’s intrinsic electrical activity. Neuronal excitability is a characteristic property of…
Effects of cannabinoids on ligand-gated ion channels
Abstract Phytocannabinoids such as Δ9-tetrahydrocannabinol and cannabidiol, endocannabinoids such as N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and synthetic cannabinoids such as CP47,497…
Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
Abstract Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and…
A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis
Abstract The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes…
Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain—Narrative Review
Abstract Neuropathic pain in humans results from an injury or disease of the somatosensory nervous system at the peripheral or…
Diversity of molecular targets and signaling pathways for CBD
Abstract Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct…
Cannabinoid interactions with ion channels and receptors
Abstract Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts on a diverse selection of membrane proteins with promising therapeutic…