Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure
Abstract Purpose: It has been known for nearly 50 years that cannabis and the psychoactive constituent Δ9-tetrahydrocannabinol (THC) reduce intraocular…
Intraocular pressure
Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure
Abstract Nearly half a century has passed since the demonstration that cannabis and its chief psychoactive component Δ9-THC lowers intraocular…
Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability
Abstract Purpose: The aim of the present study was to evaluate the utility of the relatively hydrophilic Δ9-tetrahydrocannabinol (THC) prodrugs,…
Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model
Abstract Purpose: Cannabinoids, such as Δ9-THC, act through an endogenous signaling system in the vertebrate eye that reduces IOP via…
Marijuana for Glaucoma: A Recipe for Disaster or Treatment?
Abstract Marijuana has been shown to lower intraocular pressure (IOP) but with limited duration of action and numerous adverse effects.…