Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations
Abstract Human endocannabinoid signaling is primarily mediated by the cannabinoid receptors, CB1 and CB2, which are G protein-coupled receptors (GPCRs).…
internalization
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
Abstract In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a…