inhibition mechanism

July 30, 2024

Autoregulatory mechanism of enzyme activity by the nuclear localization signal of lysine-specific demethylase 1

Abstract The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted structural elements, contains a nuclear localization…

May 14, 2024

ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase

Abstract Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily…