inborn errors of bile acid metabolism

August 10, 2025

Cannabidiol Is Associated with Improved Survival in Pancreatic Cancer and Modulation of Bile Acids and Gut Microbiota

Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies, with dismal survival rates. Cannabinoids have shown anticancer properties…

September 26, 2024

Dietary high lipid and high plant-protein affected growth performance, liver health, bile acid metabolism and gut microbiota in groupers

Abstract High lipid diets (HLD) and high plant-protein diets (HPD) exhibit potential fishmeal-saving effects but negatively impact liver health and…

April 5, 2024

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis

Abstract Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have…

September 30, 2023

Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens

Abstract Fatty liver hemorrhagic syndrome is a widespread metabolic disease in laying hens that decreases egg production and even causes…

March 6, 2023

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis

Abstract Objective: To explore the possible mechanisms of cholestasis induced by Polygoni Multiflori Radix (PM). Methods: Low and high doses…

June 3, 2020

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much…