Abstract Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral…
Abstract Cannabidiol (CBD), nonpsychotropic cannabinoid found in Cannabis sativa, is a very promising drug candidate offering many differential effects such…
Abstract This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through the formation of a cannabinoid…
Abstract Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges…
Abstract Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic…
Abstract Electronic supplementary material: The online version of this article (10.1186/s40478-019-0661-2) contains supplementary material, which is available to authorized users.…