RERE-AS1 as a regulator of immune modulation and therapeutic response in breast cancer
Abstract Background and aims: Breast cancer (BRCA) remains one of the most prevalent malignancies and a major threat to women’s…
immune checkpoint inhibitor immunotherapy
Impact of cannabinoids on cancer outcomes in patients receiving immune checkpoint inhibitor immunotherapy
Abstract Cannabinoids relieve pain, nausea, anorexia and anxiety, and improve quality of life in several cancer patients. The immunotherapy with…
GPCRs: emerging targets for novel T cell immune checkpoint therapy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00262-024-03801-7. Article type: Review Article Keywords: GPCRs, Immune checkpoint…
Epigenetic modification of PHLDA2 is associated with tumor microenvironment and unfavorable outcome of immune checkpoint inhibitor-based therapies in clear cell renal cell carcinoma
Abstract Background: A substantial proportion of patients with metastatic clear cell renal cell carcinoma (ccRCC) cannot derive benefit from immune…
Cannabinoids and the endocannabinoid system in immunotherapy: helpful or harmful?
Abstract Numerous studies in various cancer models have demonstrated that ingredients of cannabis can influence tumor growth through the endocannabinoid…
Pan-cancer analysis identifies SPEN mutation as a predictive biomarker with the efficacy of immunotherapy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-023-11235-0. Article type: Research Article Keywords: SPEN, X chromosome…
The Complete Response of a Renal Cell Carcinoma Metastatic to Brain, Lungs, and Liver to Second-Line Nivolumab: A Case Report
Abstract Metastatic renal cell carcinoma (RCC) is a therapeutic challenge to clinicians since it shows significant resistance to chemotherapy and…
A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning
Abstract Immunotherapy by using immune checkpoint inhibitors (ICI) has dramatically improved the treatment options in various cancers, increasing survival rates…