Dynamic changes of synergy relationship between lncRNA and immune checkpoint in cancer progression
Abstract In the battle between tumors and the immune system, immune evasion based on immune checkpoints (ICPs) is a critical…
immune checkpoint (ICP)
Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-89308-2. Article type: Research Article Keywords: PVRIG, Prognosis, Immune…
Pan-cancer analysis of PDGFRB: Laying the foundation for the development of targeted immunotherapy drugs
Abstract PDGFRB is a type III tyrosine-protein kinase that is abnormally expressed in various cancers and can serve as a…
SOCS1: A potential diagnostic and prognostic marker for aggressive gliomas and a new target for immunotherapy
Abstract Gliomas, the most common and deadly cancers of the central nervous system, present a unique immunological barrier that severely…
Implications of the NDC80 complex on the tumor immune microenvironment and cell growth in pan-cancer
Abstract Background: Previous evidence indicates that the NDC80 complex, a conserved spindle microtubule-binding component of the kinetochore, is overexpressed and…
TOX: a potential new immune checkpoint in cancers by pancancer analysis
Abstract Background: Thymocyte selection-associated HMG-BOX (TOX) belongs to a family of transcription factors containing a highly conserved region of the…
Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers
Abstract The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive…
Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration
Abstract Background: NADPH oxidase 4 (NOX4) has been proven to be associated with the prognosis of tumors in multiple cancers…
Identification of enhancer RNA AC005515.1 as a novel biomarker for prognosis in esophageal cancer and predictors of immunotherapy response
Abstract Background: The enhancer RNA (eRNA) signature shows excellent promise in the prognostic role of many malignancies, but its value…
Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines
Abstract Background: Ubiquitin Specific Peptidase 28 (USP28), as a member of the DUBs family, has been reported to regulate the…