Pan-cancer analysis and single-cell analysis reveals FAM110B as a potential target for survival and immunotherapy
Abstract Background: FAM110B belongs to the family that has a 110 sequence similarity (FAM110) and is located in the centrosome…
immune cells within the tumor microenvironment
Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target
Abstract The Ten-Eleven Translocation (TET) family genes are implicated in a wide array of biological functions across various human cancers.…
Pan‑cancer analysis on the role of KMT2C expression in tumor progression and immunotherapy
Abstract Histone lysine N-methyltransferase 2C (KMT2C) is involved in transcriptional regulation and DNA damage repair. Mutations in KMT2C have been…
Pan-cancer analysis of disulfidptosis with potential implications in prognosis, immune microenvironment, and drug resistance in human cancer
Abstract To get a systematic assessment of disulfidptosis-related genes across human cancers and explore the predictive role of disulfidptosis in…
Systematic Characterization of DNA Methyltransferases Family in Tumor Progression and Antitumor Immunity
Abstract Objective: DNA methylation is an essential epigenetic marker governed by DNA methyltransferases (DNMTs), which can influence cancer onset and…
Experimental Validation and Multi-omics Analysis Identified ARPC1A as a Novel Oncogene and Potential Therapeutic Target in Glioblastoma
Abstract Actin-related protein 2/3 complex subunit 1A (ARPC1A) is implicated in several cancers due to its critical role in regulating…
Next-generation sequencing identified that RET variation associates with lymph node metastasis and the immune microenvironment in thyroid papillary carcinoma
Abstract Background: To date, although most thyroid carcinoma (THCA) achieves an excellent prognosis, some patients experience a rapid progression episode,…
Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma
Abstract Background: LRRC59 is a leucine-rich repeats-containing protein located in the endoplasmic reticulum (ER), it serves as a prognostic marker…
Comprehensive Characterization of the Integrin Family Across 32 Cancer Types
Abstract Integrin genes are widely involved in tumorigenesis. Yet, a comprehensive characterization of integrin family members and their interactome at…
Pan-cancer prognosis, immune infiltration, and drug resistance characterization of lung squamous cell carcinoma tumor microenvironment-related genes
Abstract Background: The tumor microenvironment (TME) plays an important role in cancer development; however, its implications in lung squamous cell…