Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer
Abstract Background: Krüppel-like factor 3 (KLF3) is a key transcriptional repressor, which is involved in various biological functions such as…
immune cells within the tumor microenvironment
SHP2 is involved in the occurrence, development and prognosis of cancer
Abstract Src homology-2 domain-containing protein tyrosine phosphatase (SHP2), encoded by protein tyrosine phosphatase non-receptor type 11 (PTPN11), is widely expressed…
An Integrated Analysis Identified TAGLN2 As an Oncogene Indicator Related to Prognosis and Immunity in Pan-Cancer
Abstract Background: Transgelin-2 (TAGLN2) has long been regarded as an actin-binding protein that modulates actin gelation and controls actin cytoskeleton…
Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
Abstract During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Key players in the immunosuppressive…
Pan-cancer analysis of TASL: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction
Abstract Background: New immunotherapeutic strategies based on predictors are urgently needed. Toll-like receptor adaptor interacting with SLC15A4 on the lysosome…
The potential of FCRL genes as targets for cancer treatment: insights from bioinformatics and immunology
Abstract Cancer is a prevalent and dangerous disease that requires a multifaceted approach to treatment. The FCRL family gene has…
Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment
Abstract Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of…
Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering
Abstract Background: Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to…
Identifies KCTD5 as a novel cancer biomarker associated with programmed cell death and chemotherapy drug sensitivity
Abstract Background: More and more studies have demonstrated that potassium channel tetramerization domain-containing 5 (KCTD5) plays an important role in…
Immunological role and prognostic value of the SKA family in pan-cancer analysis
Abstract Background: The spindle and kinetochore associated (SKA) complex, which plays important roles in proper chromosome segregation during mitosis by…