Hallmarks of primary headache: part 3 – cluster headache
Abstract Background: Cluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain…
Hypothalamus
The Role of Hypothalamic Microglia in the Onset of Insulin Resistance and Type 2 Diabetes: A Neuro-Immune Perspective
Abstract Historically, microglial activation has been associated with diseases of a neurodegenerative and neuroinflammatory nature. Some, like Alzheimer’s disease, Parkinson’s…
The thalamus in psychosis spectrum disorder
Abstract Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a lifetime of chronic disability, causing…
Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity
Abstract Introduction: The implications of maternal overnutrition on offspring metabolic and neuroimmune development are well-known. Increasing evidence now suggests that…
Hypothalamic endocannabinoids in obesity: an old story with new challenges
Abstract The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and…
Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats
Abstract Background: Cannabidiol (CBD), the non-psychotropic compound from Cannabis sativa, shows positive results on controlling several health disturbances; however, comparable…
Sexual Dimorphisms and Asymmetries of the Thalamo-Cortical Pathways and Subcortical Grey Matter of Term Born Healthy Neonates: An Investigation with Diffusion Tensor MRI
Abstract Diffusion-tensor-MRI was performed on 28 term born neonates. For each hemisphere, we quantified separately the axial and the radial…
Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives
Abstract Borderline Personality Disorder (BPD) is a chronic debilitating psychiatric disorder characterized mainly by emotional instability, chaotic interpersonal relationships, cognitive…
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Abstract Simple Summary: Pro-inflammatory cytokines are considered to be one of the most important mediators affecting the function of central…
Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus
Abstract Background: Cannabidiol (CBD) and cannabigerol (CBG) are non-psychotropic terpenophenols isolated from Cannabis sativa, which, besides their anti-inflammatory/antioxidant effects, are…