Abstract Molecular chaperones safeguard cellular protein homeostasis and obviate proteotoxicity. In the process of aging, as chaperone networks decline, aberrant…
Abstract We recently identified Secernin-1 (SCRN1) as a novel amyloid plaque associated protein using localized proteomics. Immunohistochemistry studies confirmed that…
Abstract Alzheimer’s disease (AD) is characterized by multiple cognitive deficits including memory and sensorimotor gating impairments as a result of…
Abstract Introduction: The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases.…