Long Non-Coding RNA DUXAP10 Promotes Tumorigenesis and Metastasis in Anaplastic Thyroid Cancer
Abstract Simple Summary: Anaplastic thyroid cancer is a fast-growing and deadly malignancy. A major reason for its extremely low survival…
HER2-targeted therapy
Bone Targeted Parathyroid Hormone Antagonists for Prevention of Breast Cancer Bone Metastases
Abstract Breast cancer frequently spreads to the bones, leading to pain, fractures, and other bone-related complications. Current treatments slow the…
Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity
Abstract Background: With the sharp increase in the incidence of papillary thyroid carcinoma (PTC), the disease-specific survival rate has not…
Young lung cancer: from diagnosis to survivorship
Abstract Background: Young patients with lung cancer represent a distinct population, with unique disease and treatment-related characteristics, as well as…
Systematic Characterisation and Analysis of Lysyl Oxidase Family Members as Drivers of Tumour Progression and Multiple Drug Resistance
Abstract The intricacies of tumour microenvironment, particularly the extracellular matrix (ECM), underscore its pivotal function in modulating tumour progression and…
The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation
Abstract Background: Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an E3 ubiquitin ligase and scaffolding protein that contribute…
Optical and MRI-Guided Theranostic Application of Ultrasmall Superparamagnetic Iron Oxide Nanodrug Conjugate for PSMA-Positive Prostate Cancer Therapy
Abstract Active targeting is more effective than conventional passive targeted drug delivery systems in increasing therapeutic efficacy and minimizing systemic…
Identification of cancer-associated fibroblast subtypes and prognostic model development in breast cancer: role of the RUNX1/SDC1 axis in promoting invasion and metastasis
Abstract Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s10565-024-09950-w. Article type: Research Article Keywords: Cancer-associated…
Pan-cancer analysis and single-cell analysis reveals FAM110B as a potential target for survival and immunotherapy
Abstract Background: FAM110B belongs to the family that has a 110 sequence similarity (FAM110) and is located in the centrosome…
Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
Abstract P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its…