Abstract The inflammatory response during acute lung injury and ARDS leads to an overactive immune response, causing further damage and…
Abstract GPR18 is an orphan GPCR that is activated by the cannabinoid tetrahydrocannabinol (THC). Emerging evidence indicates its involvement in…
Abstract Simple Summary: Glioblastoma (GBM) is the most frequent primary brain tumor entity with poor prognosis and resistance to current…
Abstract O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the treatment…
Abstract GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by…
Abstract Endocannabinoids are ancient biomolecules involved in several cellular (e.g., metabolism) and physiological (e.g., eating behaviour) functions. Indeed, eating behaviour…
Abstract Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G…
Abstract Background: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids…
Abstract Electronic supplementary material: The online version of this article (doi:10.1007/s11419-016-0320-2) contains supplementary material, which is available to authorized users.…
Abstract The orphan receptor GPR18 has become a research target following the discovery of a putative endogenous agonist, N-arachidonoyl glycine…