Transcriptomic and Lipidomic Analysis Reveals the Regulatory Network of Lipid Metabolism in Cannabis sativa
Abstract Hemp possesses significant healthcare value due to its rich composition of unsaturated fatty acids and a distinctive golden ratio…
genomics and transcriptomics
Cannabinol’s Modulation of Genes Involved in Oxidative Stress Response and Neuronal Plasticity: A Transcriptomic Analysis
Abstract Cannabis sativa is a remarkable source of bioactive compounds, with over 150 distinct phytocannabinoids identified to date. Among these,…
Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer
Abstract Background: Alanine Serine Cysteine transporter 2 (ASCT2/SLC1A5) is a key glutamine transporter in cancer cells and has been shown…
Cannabinerol Restores mRNA Splicing Defects Induced by β-Amyloid in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study
Abstract Alzheimer’s disease (AD) is the most common form of dementia, characterized by β-amyloid (Aβ) plaques and neurofibrillary tangles, leading…
The promising role of nanopore sequencing in cancer diagnostics and treatment
Abstract Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a…
Liver Transcriptomic Profiles of Ruminant Species Fed Spent Hemp Biomass Containing Cannabinoids
Abstract The inclusion of spent hemp biomass (SHB), an extracted byproduct from industrial cannabidiol (CBD) production, in the diets of…
In silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution
Abstract Introduction: The endocannabinoid (eCB) system is named after the discovery that endogenous cannabinoids bind to the same receptors as…
Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination
Abstract While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send…
Detoxifying the heavy metals: a multipronged study of tolerance strategies against heavy metals toxicity in plants
Abstract Heavy metal concentrations exceeding permissible limits threaten human life, plant life, and all other life forms. Different natural and…
Cannabidiol Decreases Intestinal Inflammation in the Ovariectomized Murine Model of Postmenopause
Abstract Cannabidiol (CBD) (25 mg/kg peroral) treatment was shown to improve metabolic outcomes in ovariectomized (OVX) mice deficient in 17β-estradiol…