Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer
Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack…
gene ontology
Pan-Cancer Analysis Reveals Functional Similarity of Three lncRNAs across Multiple Tumors
Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators in many biological processes. The dysregulation of lncRNA expression has…
A functional gene module identification algorithm in gene expression data based on genetic algorithm and gene ontology
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12864-023-09157-z. Article type: Research Article Keywords: Functional gene module,…
Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence
Abstract Methods: Using data from published alcohol dependence genome-wide association studies, we first conducted a proteome-wide association study of alcohol…
Identifying key genes of classic papillary thyroid cancer in women aged more than 55 years old using bioinformatics analysis
Abstract Background: The incidence rate of thyroid carcinoma (THCA) markedly increased in the recent few decades and has been likely…
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…
Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines
Abstract The nonpsychoactive cannabinoid, cannabidiol (CBD), is Food and Dug Administration approved for treatment of two drug-resistant epileptic disorders and…
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers
Keywords: AUC, area under the curve, CCLE, cancer cell line encyclopedia, HR, hazard ratio, ROC, receiver operating characteristic, SHCBP1, Shc…
Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts
Keywords: CPH, Cox proportional hazard regression, PH, proportional hazard, TCGA, The Cancer Genome Atlas, OS, overall survival, GEO, Gene Expression…
Deep GONet: self-explainable deep neural network based on Gene Ontology for phenotype prediction from gene expression data
Abstract Background: With the rapid advancement of genomic sequencing techniques, massive production of gene expression data is becoming possible, which…