Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18
Abstract GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by…
G protein coupled receptor (GPCR)
Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure
Abstract Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid…
Pharmacogenomics of GPCR Drug Targets
Abstract Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is…
High-resolution crystal structure of the human CB1 cannabinoid receptor
Abstract The human cannabinoid G protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and…
GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine
Abstract The orphan receptor GPR18 has become a research target following the discovery of a putative endogenous agonist, N-arachidonoyl glycine…