G protein coupled receptor (GPCR)

June 1, 2020

Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer’s disease?

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the 50 million worldwide cases of dementia…

April 29, 2020

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

Abstract GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by…

October 12, 2019

Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure

Abstract Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid…

January 11, 2018

Pharmacogenomics of GPCR Drug Targets

Abstract Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is…

November 16, 2016

High-resolution crystal structure of the human CB1 cannabinoid receptor

Abstract The human cannabinoid G protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and…

March 21, 2016

GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine

Abstract The orphan receptor GPR18 has become a research target following the discovery of a putative endogenous agonist, N-arachidonoyl glycine…