farnesoid X receptor

November 4, 2025

Fibre composition in sow diets influences bile acid profile in colostrum and in intestinal digesta of their new-born suckling piglets

Abstract Dietary fibre can modify colostrum and milk composition in sows. Bile acids (BA) aid in fat digestion and lipid…

September 29, 2025

A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis

Abstract Nuclear receptor farnesoid X receptor (FXR) acts as a key regulator of bile acid pool homeostasis and metabolism. Within…

October 13, 2024

Bile acid disorders and intestinal barrier dysfunction are involved in the development of fatty liver in laying hens

Abstract The pathogenesis of fatty liver is highly intricate. The role of the gut-liver axis in the development of fatty…

March 6, 2023

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis

Abstract Objective: To explore the possible mechanisms of cholestasis induced by Polygoni Multiflori Radix (PM). Methods: Low and high doses…

August 5, 2022

Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review)

Abstract Bile acids (BAs) are the major components of bile and products of cholesterol metabolism. Cholesterol is catalyzed by a…

December 16, 2020

NASH-related increases in plasma bile acid levels depend on insulin resistance

Abstract Background & Aims: Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However,…